Outline
The efficiency of embryo implantation is surprisingly low in humans. This can either be attributed to the high rate of chromosomally abnormal embryos, or to uterine factors, if the embryo is chromosomally normal. Enormous efforts have been devoted to finding the appropriate method to identify the competent embryo, still those are either invasive, or non-objective/non-effective, or the combination of them. The invention which relates to a non-invasive, simple, inexpensive, quick method to assess embryo competence in vitro by detecting nucleic acid-containing extracellular vesicles in the culture medium of the embryo promotes finding solution for the abovementioned problems.