Outline
The invention relates to a combined, solid, oral pharmaceutical composition that is usable for diminishing or protecting against the gastro-intestinal side effects of non-steroidal anti-inflammatory agents orally administered in a therapy, which contains capsaicinoid active agent in a small dose, one or more non-steroidal anti-inflammatory active agent, and one or more usual pharmaceutical auxiliary materials, characterized by that the composition comprises the active agent and other ingredients in a vehicle system which ensures the small concentration, uniform distribution and stability of the active agent on the mucous membrane.