Applying novel imipridone derivatives, containing 3,5-disubstituted benzyl group attached to position 7, being subject of the present invention, especially on patients suffering from prostate carcinoma, pancreatic cancer, lung carcinoma, breast cancer, glioma, cancers of head and neck, colon cancer, skin cancer proved to show enhanced anticancer activity.
Mycoplasma anserisalpingitidis is a pathogen lurking in geese which poses a threat primarily to the health of geese and, less commonly, ducks.
The invention relates to the field of assessing transport activity of OATP (Organic anion-transporting polypeptide) transport proteins. In particular, the invention relates to a real-time, add-and-read fluorescence-based method for determining whether a test compound interferes with substrate transport activity of an OATP, by using a non-fluorescent control substrate which becomes fluorescent within a cell. The method is also applicable to measure the expression of an OATP and to discriminate between a transported substrate and an inhibitor of an OATP.
The invention relates to the field of assessing transport activity of OATP (Organic anion-transporting polypeptide) and ABC (ATP Binding Cassette) transport proteins. In particular, the invention relates to methods for determining in a single, fluorescence-based assay whether a compound is a modulator of OATP and/or MRP2 (Multidrug resistance associated protein, ABCC) transport activity, using a fluorescent compound that is a substrate of both OATP and MRP2, and is selected from sulfopyrenes having general formula (I) or sulforhodamines having general formula (II).
The invention relates to a polymeric indicator fixed in a polymeric gel carrier, wherein the polymeric gel carrier comprises a hydrophilic polymer, wherein the polymeric indicator and the hydrophilic polymer are present together in the form of a combined cross-linked hydrogel network fixed by chemical bonds.
Danubia Wins First Place of the Companies For The Future Award 2024
TRADEMARK PROTECTION OF A COLOUR AGAINST THE SHADE OF THE SAME COLOUR ‘MILKA’
REIMBURSEMENT OF ENRICHMENT ACHIEVED BY TRADEMARK INFRINGEMENT
Measuring and reflecting the utilization of research results in university rankings
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